Protein Details: Potassium voltage-gated channel subfamily G member 1

Protein ID

ICDB_Pro_1665

Protein Name

Potassium voltage-gated channel subfamily G member 1

Gene Name

KCNG1

Organism

Homo sapiens (Human)

Length

513 amino acids

AlphaFoldDB

AF-Q9UIX4-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1

Sequence

MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Autism Spectrum Disorder and Bladder Leiomyoma

Location

Expressed in brain and placenta; and at much lower levels in kidney and pancreas (PubMed:9434767).

DOI ID

10.1006/bbrc.1997.7830; 10.1038/ng1285; 10.1038/414865a; 10.1101/gr.2596504; 10.1074/jbc.m808786200

RefSeq

NP_002228.2 [Q9UIX4-1]; XP_006723848.1 [Q9UIX4-1]; XP_011527102.1 [Q9UIX4-1]; XP_011527103.1 [Q9UIX4-1]; XP_011527104.1 [Q9UIX4-1]; XP_011527105.1 [Q9UIX4-1]; XP_011527106.1 [Q9UIX4-1]; XP_011527107.1; XP_011527108.1 [Q9UIX4-1]